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Asymmetric, Stereodivergent Synthesis of (−)-Clusianone Utilizing a Biomimetic Cationic Cyclization

We report a stereodivergent, asymmetric total synthesis of (−)-clusianone in six steps from commercial materials. We implement a challenging cationic cyclization forging a bond between two sterically encumbered quaternary carbons. Mechanistic studies point to the unique ability of formic acid to bri...

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Bibliografiske detaljer
Main Authors: Boyce, Jonathan H., Porco, John A.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4182949/
https://ncbi.nlm.nih.gov/pubmed/24916169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201404437
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