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Hemizygous Le-Cre Transgenic Mice Have Severe Eye Abnormalities on Some Genetic Backgrounds in the Absence of LoxP Sites
Eye phenotypes were investigated in Le-Cre(Tg/−); Pax6(fl/+) mice, which were expected to show tissue-specific reduction of Pax6 in surface ectoderm derivatives. To provide a better comparison with our previous studies of Pax6(+/−) eye phenotypes, hemizygous Le-Cre(Tg/−) and heterozygous Pax6(fl/+)m...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4182886/ https://ncbi.nlm.nih.gov/pubmed/25272013 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0109193 |
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