Gemcitabine Induces Poly (ADP-Ribose) Polymerase-1 (PARP-1) Degradation through Autophagy in Pancreatic Cancer

Poly (ADP-ribose) polymerase-1 (PARP-1) and autophagy play increasingly important roles in DNA damage repair and cell death. Gemcitabine (GEM) remains the first-line chemotherapeutic drug for pancreatic cancer (PC). However, little is known about the relationship between PARP-1 expression and autoph...

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Main Authors: Wang, Yufeng, Kuramitsu, Yasuhiro, Tokuda, Kazuhiro, Baron, Byron, Kitagawa, Takao, Akada, Junko, Maehara, Shin-ichiro, Maehara, Yoshihiko, Nakamura, Kazuyuki
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4182782/
https://ncbi.nlm.nih.gov/pubmed/25271986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0109076
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