HIF-2α Regulates NANOG Expression in Human Embryonic Stem Cells following Hypoxia and Reoxygenation through the Interaction with an Oct-Sox Cis Regulatory Element

Low O(2) tension is beneficial for human embryonic stem cell (hESC) maintenance but the mechanism of regulation is unknown. HIF-2α was found to bind directly to predicted hypoxic response elements (HREs) in the proximal promoter of OCT4, NANOG and SOX2 only in hESCs cultured under hypoxia (5% O(2))....

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Autori principali: Petruzzelli, Raffaella, Christensen, David R., Parry, Kate L., Sanchez-Elsner, Tilman, Houghton, Franchesca D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4182711/
https://ncbi.nlm.nih.gov/pubmed/25271810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0108309
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