Identification of Essential Proteins Based on Ranking Edge-Weights in Protein-Protein Interaction Networks

Essential proteins are those that are indispensable to cellular survival and development. Existing methods for essential protein identification generally rely on knock-out experiments and/or the relative density of their interactions (edges) with other proteins in a Protein-Protein Interaction (PPI)...

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Main Authors: Wang, Yan, Sun, Huiyan, Du, Wei, Blanzieri, Enrico, Viero, Gabriella, Xu, Ying, Liang, Yanchun
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4182551/
https://ncbi.nlm.nih.gov/pubmed/25268881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0108716
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