Early Detection of Motor Dysfunction in the SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis (ALS) Using Home Cage Running Wheels

The SOD1(G93A) mouse has been used since 1994 for preclinical testing in amyotrophic lateral sclerosis (ALS). Despite recent genetic advances in our understanding of ALS, transgenic mice expressing mutant SOD1 remain the best available, and most widely used, vertebrate model of the disease. We previ...

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Détails bibliographiques
Auteurs principaux: Bennett, Ellen J., Mead, Richard J., Azzouz, Mimoun, Shaw, Pamela J., Grierson, Andrew J.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4182307/
https://ncbi.nlm.nih.gov/pubmed/25268710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0107918
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