Inhibition of Nek2 by Small Molecules Affects Proteasome Activity

Background. Nek2 is a serine/threonine kinase localized to the centrosome. It promotes cell cycle progression from G2 to M by inducing centrosome separation. Recent studies have shown that high Nek2 expression is correlated with drug resistance in multiple myeloma patients. Materials and Methods. To...

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Main Authors: Meng, Lingyao, Carpenter, Kent, Mollard, Alexis, Vankayalapati, Hariprasad, Warner, Steven L., Sharma, Sunil, Tricot, Guido, Zhan, Fenghuang, Bearss, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4182079/
https://ncbi.nlm.nih.gov/pubmed/25313354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/273180
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