Enhanced Genetic Modification of Adult Growth Factor Mobilized Peripheral Blood Hematopoietic Stem and Progenitor Cells With Rapamycin

Genetic modification of adult human hematopoietic stem and progenitor cells (HSPCs) with lentiviral vectors leads to long-term gene expression in the progeny of the HSPCs and has been used to successfully treat several monogenic diseases. In some cases, the gene-modified cells have a selective growt...

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Bibliografiska uppgifter
Huvudupphovsmän: Li, Lijing, Torres-Coronado, Mónica, Gu, Angel, Rao, Anitha, Gardner, Agnes M., Epps, Elizabeth W., Gonzalez, Nancy, Tran, Chy-Anh, Wu, Xiwei, Wang, Jin-Hui, DiGiusto, David L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: AlphaMed Press 2014
Ämnen:
Protocols and Manufacturing for Cell-Based Therapies
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4181393/
https://ncbi.nlm.nih.gov/pubmed/25107584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5966/sctm.2014-0010
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