SubcloneSeeker: a computational framework for reconstructing tumor clone structure for cancer variant interpretation and prioritization

Many tumors are composed of genetically divergent cell subpopulations. We report SubcloneSeeker, a package capable of exhaustive identification of subclone structures and evolutionary histories with bulk somatic variant allele frequency measurements from tumor biopsies. We present a statistical fram...

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Main Authors: Qiao, Yi, Quinlan, Aaron R, Jazaeri, Amir A, Verhaak, Roeland GW, Wheeler, David A, Marth, Gabor T
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2014
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Method
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180956/
https://ncbi.nlm.nih.gov/pubmed/25160522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-014-0443-x
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