Disturbed Flow Enhances Inflammatory Signaling and Atherogenesis by Increasing Thioredoxin-1 Level in Endothelial Cell Nuclei

BACKGROUND: Oxidative stress occurs with disturbed blood flow, inflammation and cardiovascular disease (CVD), yet free-radical scavenging antioxidants have shown limited benefit in human CVD. Thioredoxin-1 (Trx1) is a thiol antioxidant protecting against non-radical oxidants by controlling protein t...

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Main Authors: Go, Young-Mi, Son, Dong Ju, Park, Heonyong, Orr, Michael, Hao, Li, Takabe, Wakako, Kumar, Sandeep, Kang, Dong Won, Kim, Chan Woo, Jo, Hanjoong, Jones, Dean P.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180949/
https://ncbi.nlm.nih.gov/pubmed/25265386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0108346
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