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Whole-genome haplotype reconstruction using proximity-ligation and shotgun sequencing
Rapid advances in high-throughput sequencing facilitate variant discovery and genotyping, but linking variants into a single haplotype remains challenging. Here we demonstrate HaploSeq, an approach for assembling chromosome-scale haplotypes by exploiting the existence of ‘chromosome territories’. We...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4180835/ https://ncbi.nlm.nih.gov/pubmed/24185094 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.2728 |
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