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Inhibition of human glutamine synthetase by L-methionine-S,R-sulfoximine – relevance to the treatment of neurological diseases

At high concentrations, the glutamine synthetase inhibitor L-methionine-S,R-sulfoximine is a convulsant, especially in dogs. Nevertheless, sub-convulsive doses of MSO are neuroprotective in rodent models of hyperammonemia, acute liver disease, and amyotrophic lateral sclerosis and suggest MSO may be...

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Detaylı Bibliyografya
Asıl Yazarlar: Jeitner, Thomas M., Cooper, Arthur J. L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180818/
https://ncbi.nlm.nih.gov/pubmed/24136581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11011-013-9439-6
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