SPC3, a synthetic peptide derived from the V3 domain of human immunodeficiency virus type 1 (HIV-1) gp120, inhibits HIV-1 entry into CD4+ and CD4- cells by two distinct mechanisms.

Eitemau Tebyg

• Synthetic multimeric peptides derived from the principal neutralization domain (V3 loop) of human immunodeficiency virus type 1 (HIV-1) gp120 bind to galactosylceramide and block HIV-1 infection in a human CD4-negative mucosal epithelial cell line.
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  Cyhoeddwyd: (1995)
• Human Erythrocyte Glycosphingolipids as Alternative Cofactors for Human Immunodeficiency Virus Type 1 (HIV-1) Entry: Evidence for CD4-Induced Interactions between HIV-1 gp120 and Reconstituted Membrane Microdomains of Glycosphingolipids (Gb3 and GM3)
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  Cyhoeddwyd: (1999)
• Multibranched V3 peptides inhibit human immunodeficiency virus infection in human lymphocytes and macrophages.
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  Cyhoeddwyd: (1994)
• Structure of an HIV-2 gp120 in Complex with CD4
  gan: Davenport, Yunji W., et al.
  Cyhoeddwyd: (2016)
• Conformational alterations in the CD4 binding cavity of HIV-1 gp120 influencing gp120-CD4 interactions and fusogenicity of HIV-1 envelopes derived from brain and other tissues
  gan: Gray, Lachlan, et al.
  Cyhoeddwyd: (2011)