FTY720 Shows Promising In vitro and In vivo Preclinical Activity by Downmodulating Cyclin D1 and Phospho-Akt in Mantle Cell Lymphoma

PURPOSE: Despite the progress that has been made in the treatment of mantle cell lymphoma (MCL), all patients invariably relapse with the currently available therapies. Because of the absence of curative therapy for MCL, we explored FTY720 as a novel agent against MCL. EXPERIMENTAL DESIGN: The cytot...

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Main Authors: Liu, Qing, Alinari, Lapo, Chen, Ching-Shih, Yan, Fengting, Dalton, James T., Lapalombella, Rosa, Zhang, Xiaoli, Mani, Rajeswaran, Lin, Teresa, Byrd, John C., Baiocchi, Robert A., Muthusamy, Natarajan
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180653/
https://ncbi.nlm.nih.gov/pubmed/20460491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-2484
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