FTY720 Shows Promising In vitro and In vivo Preclinical Activity by Downmodulating Cyclin D1 and Phospho-Akt in Mantle Cell Lymphoma

PURPOSE: Despite the progress that has been made in the treatment of mantle cell lymphoma (MCL), all patients invariably relapse with the currently available therapies. Because of the absence of curative therapy for MCL, we explored FTY720 as a novel agent against MCL. EXPERIMENTAL DESIGN: The cytot...

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Hauptverfasser: Liu, Qing, Alinari, Lapo, Chen, Ching-Shih, Yan, Fengting, Dalton, James T., Lapalombella, Rosa, Zhang, Xiaoli, Mani, Rajeswaran, Lin, Teresa, Byrd, John C., Baiocchi, Robert A., Muthusamy, Natarajan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180653/
https://ncbi.nlm.nih.gov/pubmed/20460491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-2484
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