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Thermal Stabilty of Glucokinase (GK) as Influenced by the Substrate Glucose, an Allosteric Glucokinase Activator Drug (GKA) and the Osmolytes Glycerol and Urea
We investigated how glycerol, urea, glucose and a GKA influence kinetics and stability of wildtype and mutant GK. Glycerol and glucose stabilized GK additively. Glycerol barely affected the TF spectra of all GKs but decreased k(cat), glucose S(0.5) and K(D) values and ATP K(M) while leaving cooperat...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4180501/ https://ncbi.nlm.nih.gov/pubmed/22446163 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2012.03.003 |
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