The Amyloid Precursor Protein Controls Adult Hippocampal Neurogenesis through GABAergic Interneurons

Impaired neurogenesis in the adult hippocampus has been implicated in AD pathogenesis. Here we reveal that the APP plays an important role in the neural progenitor proliferation and newborn neuron maturation in the mouse dentate gyrus. APP controls adult neurogenesis through a noncell-autonomous mec...

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Hlavní autoři: Wang, Baiping, Wang, Zilai, Sun, Lu, Yang, Li, Li, Hongmei, Cole, Allysa L., Rodriguez-Rivera, Jennifer, Lu, Hui-Chen, Zheng, Hui
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180470/
https://ncbi.nlm.nih.gov/pubmed/25274811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2848-14.2014
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