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Activated Notch Causes Deafness by Promoting a Supporting Cell Phenotype in Developing Auditory Hair Cells
PURPOSE: To determine whether activated Notch can promote a supporting cell fate during sensory cell differentiation in the inner ear. METHODS: An activated form of the Notch1 receptor (NICD) was expressed in early differentiating hair cells using a Gfi1-Cre mouse allele. To determine the effects of...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4180070/ https://ncbi.nlm.nih.gov/pubmed/25264928 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0108160 |
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