Imaging flow cytometry for automated detection of hypoxia-induced erythrocyte shape change in sickle cell disease

In preclinical and early phase pharmacologic trials in sickle cell disease, the percentage of sickled erythrocytes after deoxygenation, an ex vivo functional sickling assay, has been used as a measure of a patient’s disease outcome. We developed a new sickle imaging flow cytometry assay (SIFCA) and...

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Main Authors: van Beers, Eduard J., Samsel, Leigh, Mendelsohn, Laurel, Saiyed, Rehan, Fertrin, Kleber Y., Brantner, Christine A., Daniels, Mathew P., Nichols, James, McCoy, J. Philip, Kato, Gregory J.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180063/
https://ncbi.nlm.nih.gov/pubmed/24585634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajh.23699
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