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Efficient in vivo deletion of a large imprinted lncRNA by CRISPR/Cas9

Recent genome-wide studies have revealed that the majority of the mouse genome is transcribed as non-coding RNAs (ncRNAs) and growing evidence supports the importance of ncRNAs in regulating gene expression and epigenetic processes. However, the low efficiency of conventional gene targeting strategi...

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מידע ביבליוגרפי
Main Authors: Han, Jinxiong, Zhang, Jun, Chen, Li, Shen, Bin, Zhou, Jiankui, Hu, Bian, Du, Yinan, Tate, Peri H, Huang, Xingxu, Zhang, Wensheng
פורמט: Artigo
שפה:Inglês
יצא לאור: Landes Bioscience 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4179957/
https://ncbi.nlm.nih.gov/pubmed/25137067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/rna.29624
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