Administration of interleukin 12 in combination with type II collagen induces severe arthritis in DBA/1 mice.

The induction of arthritis in DBA/1 mice usually requires immunization with the antigen type II collagen emulsified with Mycobacterium tuberculosis in oil. Here we describe that interleukin 12 (IL-12) can replace mycobacteria and cause severe arthritis of DBA/1 mice when administered in combination...

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Detalhes bibliográficos
Main Authors: Germann, T, Szeliga, J, Hess, H, Störkel, S, Podlaski, F J, Gately, M K, Schmitt, E, Rüde, E
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC41799/
https://ncbi.nlm.nih.gov/pubmed/7761407
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