Immunologic Effects of Hydroxyurea in Sickle Cell Anemia

BACKGROUND AND OBJECTIVE: Susceptibility to encapsulated bacteria is well known in sickle cell disease (SCD). Hydroxyurea use is common in adults and children with SCD, but little is known about hydroxyurea’s effects on immune function in SCD. Because hydroxyurea inhibits ribonucleotide reductase, c...

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Main Authors: Lederman, Howard M., Connolly, Margaret A., Kalpatthi, Ram, Ware, Russell E., Wang, Winfred C., Luchtman-Jones, Lori, Waclawiw, Myron, Goldsmith, Jonathan C., Swift, Andrea, Casella, James F.
Format: Artigo
Jezik:Inglês
Izdano: American Academy of Pediatrics 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4179098/
https://ncbi.nlm.nih.gov/pubmed/25180279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1542/peds.2014-0571
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