The P4-P2′ Amino Acids Surrounding Human Norovirus Polyprotein Cleavage Sites Define the Core Sequence Regulating Self-Processing Order

Noroviruses (NoV) are members of the family Caliciviridae. The human NoV open reading frame 1 (ORF1) encodes a 200-kDa polyprotein which is cleaved by the viral 20-kDa 3C-like protease (Pro, NS6) into 6 nonstructural proteins that are necessary for viral replication. The NoV ORF1 polyprotein is proc...

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Päätekijät: May, Jared, Viswanathan, Prasanth, Ng, Kenneth K.-S., Medvedev, Alexei, Korba, Brent
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2014
Aiheet:
Genome Replication and Regulation of Viral Gene Expression
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178882/
https://ncbi.nlm.nih.gov/pubmed/24991013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01357-14
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