TRIM13 Is a Negative Regulator of MDA5-Mediated Type I Interferon Production

Retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) are essential intracellular detectors of viral RNA. They contribute to the type I interferon (IFN) response that is crucial for host defense against viral infections. Given the potent antiviral and proinflam...

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Main Authors: Narayan, Kavitha, Waggoner, Lisa, Pham, Serena T., Hendricks, Gabriel L., Waggoner, Stephen N., Conlon, Joseph, Wang, Jennifer P., Fitzgerald, Katherine A., Kang, Joonsoo
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2014
Assuntos:
Pathogenesis and Immunity
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178852/
https://ncbi.nlm.nih.gov/pubmed/25008915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02593-13
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