Impact of Sequence Variation in a Dominant HLA-A*02-Restricted Epitope in Hepatitis C Virus on Priming and Cross-Reactivity of CD8(+) T Cells

CD8(+) T cells are an essential component of successful adaptive immune responses against hepatitis C virus (HCV). A major obstacle to vaccine design against HCV is its inherent viral sequence diversity. Here, we test the hypothesis that different sequence variants of an immunodominant CD8(+) T cell...

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Detalhes bibliográficos
Main Authors: Ziegler, Susanne, Skibbe, Kathrin, Walker, Andreas, Ke, Xiaoyu, Heinemann, Falko M., Heinold, Andreas, Mok, Juk Yee, van Esch, Wim J. E., Yang, Dongliang, Wölfl, Matthias, Timm, Jörg
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178828/
https://ncbi.nlm.nih.gov/pubmed/25008925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01590-14
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