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Adeno-Associated Virus Type 2 Wild-Type and Vector-Mediated Genomic Integration Profiles of Human Diploid Fibroblasts Analyzed by Third-Generation PacBio DNA Sequencing

Genome-wide analysis of adeno-associated virus (AAV) type 2 integration in HeLa cells has shown that wild-type AAV integrates at numerous genomic sites, including AAVS1 on chromosome 19q13.42. Multiple GAGY/C repeats, resembling consensus AAV Rep-binding sites are preferred, whereas rep-deficient AA...

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Detalhes bibliográficos
Main Authors: Hüser, Daniela, Gogol-Döring, Andreas, Chen, Wei, Heilbronn, Regine
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178796/
https://ncbi.nlm.nih.gov/pubmed/25031342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01356-14
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