New Small-Molecule Inhibitors Effectively Blocking Picornavirus Replication

Few drugs targeting picornaviruses are available, making the discovery of antivirals a high priority. Here, we identified and characterized three compounds from a library of kinase inhibitors that block replication of poliovirus, coxsackievirus B3, and encephalomyocarditis virus. Using an in vitro t...

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Detalhes bibliográficos
Main Authors: Ford Siltz, Lauren A., Viktorova, Ekaterina G., Zhang, Ben, Kouiavskaia, Diana, Dragunsky, Eugenia, Chumakov, Konstantin, Isaacs, Lyle, Belov, George A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178779/
https://ncbi.nlm.nih.gov/pubmed/25008939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01877-14
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