Spleen Tyrosine Kinase Inhibition Attenuates Autoantibody Production and Reverses Experimental Autoimmune GN

Spleen tyrosine kinase (SYK) has an important role in immunoreceptor signaling, and SYK inhibition has accordingly attenuated immune-mediated injury in several in vivo models. However, the effect of SYK inhibition on autoantibody production remains unclear, and SYK inhibition has not been studied in...

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Autori principali: McAdoo, Stephen P., Reynolds, John, Bhangal, Gurjeet, Smith, Jennifer, McDaid, John P., Tanna, Anisha, Jackson, William D., Masuda, Esteban S., Cook, H. Terence, Pusey, Charles D., Tam, Frederick W.K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2014
Soggetti:
Basic Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178438/
https://ncbi.nlm.nih.gov/pubmed/24700868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013090978
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