Quinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cells

BACKGROUND: Most normal cells in the presence of oxygen utilize glucose for mitochondrial oxidative phosphorylation. In contrast, many cancer cells rapidly convert glucose to lactate in the cytosol, a process termed aerobic glycolysis. This glycolytic phenotype is enabled by lactate dehydrogenase (L...

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Autori principali: Billiard, Julia, Dennison, Jennifer B, Briand, Jacques, Annan, Roland S, Chai, Deping, Colón, Mariela, Dodson, Christopher S, Gilbert, Seth A, Greshock, Joel, Jing, Junping, Lu, Hong, McSurdy-Freed, Jeanelle E, Orband-Miller, Lisa A, Mills, Gordon B, Quinn, Chad J, Schneck, Jessica L, Scott, Gilbert F, Shaw, Anthony N, Waitt, Gregory M, Wooster, Richard F, Duffy, Kevin J
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2013
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178217/
https://ncbi.nlm.nih.gov/pubmed/24280423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2049-3002-1-19
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