Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress

BACKGROUND: A variety of oncogenic and environmental factors alter tumor metabolism to serve the distinct cellular biosynthetic and bioenergetic needs present during oncogenesis. Extracellular acidosis is a common microenvironmental stress in solid tumors, but little is known about its metabolic inf...

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Bibliographic Details
Main Authors: LaMonte, Gregory, Tang, Xiaohu, Chen, Julia Ling-Yu, Wu, Jianli, Ding, Chien-Kuang Cornelia, Keenan, Melissa M, Sangokoya, Carolyn, Kung, Hsiu-Ni, Ilkayeva, Olga, Boros, László G, Newgard, Christopher B, Chi, Jen-Tsan
Format: Artigo
Language:Inglês
Published: BioMed Central 2013
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178214/
https://ncbi.nlm.nih.gov/pubmed/24359630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2049-3002-1-23
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