α(1)-antitrypsin modulates microglial-mediated neuroinflammation and protects microglial cells from amyloid-β-induced toxicity

BACKGROUND: One hallmark of Alzheimer disease is microglial activation. Therapeutic approaches for this neurodegenerative disease include the modulation of microglial cells. α(1)-antitrypsin (A1AT) has been shown to exert anti-inflammatory effects on macrophages and lung epithelial cells and an inhi...

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Detalhes bibliográficos
Main Authors: Gold, Maike, Dolga, Amalia M, Koepke, Janine, Mengel, David, Culmsee, Carsten, Dodel, Richard, Koczulla, Andreas Rembert, Bach, Jan-Philipp
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4177587/
https://ncbi.nlm.nih.gov/pubmed/25245568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-014-0165-8
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