ARTD1/PARP1 negatively regulates glycolysis by inhibiting hexokinase 1 independent of NAD(+) depletion

ARTD1 (PARP1) is a key enzyme involved in DNA repair by synthesizing poly(ADP-ribose) (PAR) in response to strand breaks and plays an important role in cell death following excessive DNA damage. ARTD1-induced cell death is associated with NAD(+) depletion and ATP loss, however the molecular mechanis...

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Detalhes bibliográficos
Main Authors: Fouquerel, Elise, Goellner, Eva M., Yu, Zhongxun, Gagné, Jean-Philippe, de Moura, Michelle Barbi, Feinstein, Tim, Wheeler, David, Redpath, Philip, Li, Jianfeng, Romero, Guillermo, Migaud, Marie, Van Houten, Bennett, Poirier, Guy G., Sobol, Robert W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4177344/
https://ncbi.nlm.nih.gov/pubmed/25220464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.08.036
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