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Both retention and recirculation contribute to long-lived regulatory T cell accumulation in the thymus
Natural regulatory T cells (Tregs) acquire their lineage-determining transcription factor Foxp3 during development in the thymus and play an important role in maintaining immunologic tolerance. Here we analyzed the composition of the thymic Treg pool using RAG2-GFP/FoxP3-RFP dual reporter mice and f...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4177035/ https://ncbi.nlm.nih.gov/pubmed/24894919 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201444529 |
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