Antifungal drug resistance evokedvia RNAi-dependent epimutations

Microorganisms evolve via mechanisms spanning sexual/parasexual reproduction, mutators, aneuploidy, Hsp90, and even prions. Mechanisms that may seem detrimental can be repurposed to generate diversity. Here we show the human fungal pathogen Mucor circinelloides develops spontaneous resistance to the...

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Main Authors: Calo, Silvia, Shertz-Wall, Cecelia, Lee, Soo Chan, Bastidas, Robert J., Nicolás, Francisco E., Granek, Joshua A., Mieczkowski, Piotr, Torres-Martinez, Santiago, Ruiz-Vazquez, Rosa M., Cardenas, Maria E., Heitman, Joseph
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4177005/
https://ncbi.nlm.nih.gov/pubmed/25079329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13575
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