Complex MSH2 and MSH6 mutations in hypermutated microsatellite unstable advanced prostate cancer

A hypermutated subtype of advanced prostate cancer was recently described, but prevalence and mechanisms have not been well-characterized. Here we find that 12% (7 of 60) of advanced prostate cancers are hypermutated, and that all hypermutated cancers have mismatch repair gene mutations and microsat...

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Detaylı Bibliyografya
Asıl Yazarlar: Pritchard, Colin C., Morrissey, Colm, Kumar, Akash, Zhang, Xiaotun, Smith, Christina, Coleman, Ilsa, Salipante, Stephen J., Milbank, Jennifer, Yu, Ming, Grady, William M., Tait, Jonathan F., Corey, Eva, Vessella, Robert L., Walsh, Tom, Shendure, Jay, Nelson, Peter S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Pub. Group 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176888/
https://ncbi.nlm.nih.gov/pubmed/25255306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5988
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