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The significance of spliceosome mutations in chronic lymphocytic leukemia

Cellular proteins produced via alternative splicing, provide neoplastic cells with survival advantage and/or promote neoplastic cell proliferation. Pre-mRNA is spliced by the spliceosome consisting of large complexes of small nuclear RNA (snRNA) and protein subunits. Spliceosome gene mutations were...

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Detalhes bibliográficos
Main Authors: Rozovski, Uri, Keating, Michael, Estrov, Zeev
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176818/
https://ncbi.nlm.nih.gov/pubmed/23270583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10428194.2012.742528
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