The interferon signaling antagonist function of yellow fever virus NS5 protein is activated by Type I interferon

To successfully establish infection Flaviviruses have to overcome the antiviral state induced by type I interferon (IFN-I). The nonstructural NS5 proteins of several flaviviruses antagonize IFN-I signaling. Here we show that yellow fever virus (YFV) inhibits IFN-I signaling through a unique mechanis...

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Bibliographische Detailangaben
Hauptverfasser: Laurent-Rolle, Maudry, Morrison, Juliet, Rajsbaum, Ricardo, Macleod, Jesica M. Levingston, Pisanelli, Giuseppe, Pham, Alissa, Ayllon, Juan, Miorin, Lisa, Martinez, Carles, tenOever, Benjamin R, García-Sastre, Adolfo
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176702/
https://ncbi.nlm.nih.gov/pubmed/25211074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2014.07.015
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