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Effects of supercoiling on enhancer–promoter contacts

Using Brownian dynamics simulations, we investigate here one of possible roles of supercoiling within topological domains constituting interphase chromosomes of higher eukaryotes. We analysed how supercoiling affects the interaction between enhancers and promoters that are located in the same or in...

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Autori principali: Benedetti, Fabrizio, Dorier, Julien, Stasiak, Andrzej
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176356/
https://ncbi.nlm.nih.gov/pubmed/25123662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku759
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