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Effects of supercoiling on enhancer–promoter contacts

Using Brownian dynamics simulations, we investigate here one of possible roles of supercoiling within topological domains constituting interphase chromosomes of higher eukaryotes. We analysed how supercoiling affects the interaction between enhancers and promoters that are located in the same or in...

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Detalhes bibliográficos
Main Authors: Benedetti, Fabrizio, Dorier, Julien, Stasiak, Andrzej
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176356/
https://ncbi.nlm.nih.gov/pubmed/25123662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku759
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