ATM-depletion in breast cancer cells confers sensitivity to PARP inhibition

BACKGROUND: Mutations in the DNA damage response (DDR) factors, breast cancer 1 (BRCA1) and BRCA2, sensitize tumor cells to poly(ADP-ribose) polymerase (PARP) inhibitors. The ataxia telangiectasia mutated (ATM) kinase is a key DDR protein whose heterozygous germline mutation is a moderate–risk facto...

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Bibliografski detalji
Glavni autori: Gilardini Montani, Maria Saveria, Prodosmo, Andrea, Stagni, Venturina, Merli, Dania, Monteonofrio, Laura, Gatti, Veronica, Gentileschi, Maria Pia, Barilà, Daniela, Soddu, Silvia
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2013
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176289/
https://ncbi.nlm.nih.gov/pubmed/24252502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-9966-32-95
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