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ATM-depletion in breast cancer cells confers sensitivity to PARP inhibition
BACKGROUND: Mutations in the DNA damage response (DDR) factors, breast cancer 1 (BRCA1) and BRCA2, sensitize tumor cells to poly(ADP-ribose) polymerase (PARP) inhibitors. The ataxia telangiectasia mutated (ATM) kinase is a key DDR protein whose heterozygous germline mutation is a moderate–risk facto...
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Main Authors: | , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
BioMed Central
2013
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4176289/ https://ncbi.nlm.nih.gov/pubmed/24252502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-9966-32-95 |
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