Overexpression of Galnt3 in Chondrocytes Resulted in Dwarfism Due to the Increase of Mucin-type O-Glycans and Reduction of Glycosaminoglycans

Galnt3, UDP-N-acetyl-α-d-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3, transfers N-acetyl-d-galactosamine to serine and threonine residues, initiating mucin type O-glycosylation of proteins. We searched the target genes of Runx2, which is an essential transcription factor for chondr...

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Hauptverfasser: Yoshida, Carolina Andrea, Kawane, Tetsuya, Moriishi, Takeshi, Purushothaman, Anurag, Miyazaki, Toshihiro, Komori, Hisato, Mori, Masako, Qin, Xin, Hashimoto, Ayako, Sugahara, Kazuyuki, Yamana, Kei, Takada, Kenji, Komori, Toshihisa
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Developmental Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176229/
https://ncbi.nlm.nih.gov/pubmed/25107907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.555987
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