The Duplicated α7 Subunits Assemble and Form Functional Nicotinic Receptors with the Full-length α7

The α7 nicotinic acetylcholine receptor gene (CHRNA7) is linked to schizophrenia. A partial duplication of CHRNA7 (CHRFAM7A) is found in humans on 15q13–14. Exon 6 of CHRFAM7A harbors a 2-bp deletion polymorphism, CHRFAM7AΔ2bp, which is also associated with schizophrenia. To understand the effects o...

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Bibliografiske detaljer
Main Authors: Wang, Ying, Xiao, Cheng, Indersmitten, Tim, Freedman, Robert, Leonard, Sherry, Lester, Henry A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Neurobiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176222/
https://ncbi.nlm.nih.gov/pubmed/25056953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.582858
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