Unfolded Protein Response Is Required for the Definitive Endodermal Specification of Mouse Embryonic Stem Cells via Smad2 and β-Catenin Signaling

Tremendous efforts have been made to elucidate the molecular mechanisms that control the specification of definitive endoderm cell fate in gene knockout mouse models and ES cell (ESC) differentiation models. However, the impact of the unfolded protein response (UPR), because of the stress of the end...

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Bibliografiske detaljer
Main Authors: Xu, Huiming, Tsang, Kam Sze, Wang, Yonghui, Chan, Juliana CN, Xu, Gang, Gao, Wei-Qiang
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Developmental Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176215/
https://ncbi.nlm.nih.gov/pubmed/25092289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.572560
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