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B Cell Lymphoma-2 (BCL-2) Homology Domain 3 (BH3) Mimetics Demonstrate Differential Activities Dependent upon the Functional Repertoire of Pro- and Anti-apoptotic BCL-2 Family Proteins

The B cell lymphoma-2 (BCL-2) family is the key mediator of cellular sensitivity to apoptosis during pharmacological interventions for numerous human pathologies, including cancer. There is tremendous interest to understand how the proapoptotic BCL-2 effector members (e.g. BCL-2-associated X protein...

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Autors principals: Renault, Thibaud T., Elkholi, Rana, Bharti, Archana, Chipuk, Jerry E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176207/
https://ncbi.nlm.nih.gov/pubmed/25096574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.569632
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