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Possible involvement of self-defense mechanisms in the preferential vulnerability of the striatum in Huntington's disease
HD is caused by a mutation in the huntingtin gene that consists in a CAG repeat expansion translated into an abnormal poly-glutamine (polyQ) tract in the huntingtin (Htt) protein. The most striking neuropathological finding in HD is the atrophy of the striatum. The regional expression of mutant Htt...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4176035/ https://ncbi.nlm.nih.gov/pubmed/25309327 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2014.00295 |
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