Adipose and leptomeningeal arteriole endothelial dysfunction induced by β-amyloid peptide: a practical human model to study Alzheimer's disease vasculopathy

BACKGROUND: Evidence point to vascular dysfunction and hypoperfusion as early abnormalities in Alzheimer's disease (AD); probing their mechanistic bases can lead to new therapeutic approaches. We tested the hypotheses that β-amyloid peptide induces endothelial dysfunction and oxidative stress i...

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Detalhes bibliográficos
Main Authors: Truran, Seth, Franco, Daniel A., Roher, Alex E., Beach, Thomas G., Burciu, Camelia, Serrano, Geidy, Maarouf, Chera L., Schwab, Sara, Anderson, Jenna, Georges, Joseph, Reaven, Peter, Migrino, Raymond Q.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175686/
https://ncbi.nlm.nih.gov/pubmed/25004204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneumeth.2014.06.014
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