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Antiparallel Triple-strand Architecture for Prefibrillar Aβ42 Oligomers
Aβ42 oligomers play key roles in the pathogenesis of Alzheimer disease, but their structures remain elusive partly due to their transient nature. Here, we show that Aβ42 in a fusion construct can be trapped in a stable oligomer state, which recapitulates characteristics of prefibrillar Aβ42 oligomer...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4175361/ https://ncbi.nlm.nih.gov/pubmed/25118290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.569004 |
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