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Antiparallel Triple-strand Architecture for Prefibrillar Aβ42 Oligomers

Aβ42 oligomers play key roles in the pathogenesis of Alzheimer disease, but their structures remain elusive partly due to their transient nature. Here, we show that Aβ42 in a fusion construct can be trapped in a stable oligomer state, which recapitulates characteristics of prefibrillar Aβ42 oligomer...

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Detalhes bibliográficos
Main Authors: Gu, Lei, Liu, Cong, Stroud, James C., Ngo, Sam, Jiang, Lin, Guo, Zhefeng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175361/
https://ncbi.nlm.nih.gov/pubmed/25118290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.569004
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