Oxidation of an Exposed Methionine Instigates the Aggregation of Glyceraldehyde-3-phosphate Dehydrogenase

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a ubiquitous and abundant protein that participates in cellular energy production. GAPDH normally exists in a soluble form; however, following necrosis, GAPDH and numerous other intracellular proteins convert into an insoluble disulfide-cross-linke...

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Bibliographic Details
Main Authors: Samson, Andre L., Knaupp, Anja S., Kass, Itamar, Kleifeld, Oded, Marijanovic, Emilia M., Hughes, Victoria A., Lupton, Chris J., Buckle, Ashley M., Bottomley, Stephen P., Medcalf, Robert L.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175333/
https://ncbi.nlm.nih.gov/pubmed/25086035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.570275
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