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Maternal Aldehyde Elimination during Pregnancy Preserves the Fetal Genome
Maternal metabolism provides essential nutrients to enable embryonic development. However, both mother and embryo produce reactive metabolites that can damage DNA. Here we discover how the embryo is protected from these genotoxins. Pregnant mice lacking Aldh2, a key enzyme that detoxifies reactive a...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cell Press
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4175174/ https://ncbi.nlm.nih.gov/pubmed/25155611 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.07.010 |
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