Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells

Haematopoietic stem cells renew blood. Accumulation of DNA damage in these cells promotes their decline, while misrepair of this damage initiates malignancies. Here we describe the features and mutational landscape of DNA damage caused by acetaldehyde, an endogenous and alcohol-derived metabolite. T...

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Bibliographic Details
Published in:Nature
Main Authors: Garaycoechea, Juan I., Crossan, Gerry P., Langevin, Frederic, Mulderrig, Lee, Louzada, Sandra, Yang, Fentang, Guilbaud, Guillaume, Park, Naomi, Roerink, Sophie, Nik-Zainal, Serena, Stratton, Michael R, Patel, Ketan J
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047743/
https://ncbi.nlm.nih.gov/pubmed/29323295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature25154
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